Traditional cultures have known about the health-supporting powers of the Cannabis sativa plant for centuries; however, it is not until recently that science has been able to explain the connection between the endocannabinoid system and CBD, and why the cannabis plant has such a profound effect on virtually every system of the human body. Now, with modern science, we know that the role of CBD and the endocannabinoid system plays a part in allergies, stress, and social anxiety!
What is the Endocannabinoid System and How Does It Recognize CBD?
In 1988, Allyn Howlett and Wiliam Devane discovered the endocannabinoid system—a system of receptors or “neurotransmitters” in the brain that respond to the compounds in the cannabis plant.
While scientists initially thought that these endocannabinoid system and CBD receptors were only found in the central nervous system and the brain, they later discovered that cannabinoid receptors (CB receptors) — the body’s cannabinoid-like molecules called endocannabinoids (eCBs) — and enzymes that synthesize and break down these molecules can be found throughout the body!
Two Kinds of CB Receptors
At present, two kinds of CB receptors have been identified: CB1 receptors, which are located in the brain and regulate brain functions like memory and thinking, and CB2 receptors, which are located mainly in the peripheral nervous system and have to do with immunity and inflammation.
The Role of the Endocannabinoid System in the Human Body
So, if endocannabinoids exist naturally throughout the body (“endo” meaning “inside”), what is the role of the endocannabinoid system in promoting health and how does the interaction between the endocannabinoid system and CBD take place, seeing as cannabidiol (CBD) is a phytocannabinoid (“Phyto” meaning “plant”)?
What scientists have observed through multiple studies is that endocannabinoids (eCBs) work to maintain homeostasis or harmony in the body so that it can adjust to changes in the external environment. The processes regulated by these versatile molecules are wide-ranging and include immune function, reproductive function, skin health, sleep, stress, metabolism, appetite levels, digestive health, colon cell health, liver health, brain health, psychological health, memory, mood, and pain.
How Phytocannabinoids Interact with the Body’s Endocannabinoid System
When phytocannabinoids are ingested in the form of the whole leaf or as a derivative such as CBD oil, they trigger a response from the body’s CB receptors. In the case of the endocannabinoid system and CBD, tetrahydrocannabinol (THC) appears to activate and suppress the body’s CB receptors as well as bind to these receptors to varying degrees. CBD promotes the production of the body’s eCBs and modifies the way that other cannabinoids (like THC) bind to the receptors.
Supplying plant-based cannabinoids to the body can be helpful when the body’s own CBs have been reduced due to inappropriate diet, sleep, and exercise habits, excessive stress, and the presence of toxic chemicals such as BPA from plastic bottles and paper receipts (connected with altered pregnancy outcomes and the development of fatty liver). When you take CBD oil, the endocannabinoid system and CBD can work together to return harmony and health to the affected systems.
The Endocannabinoid System and CBD
So, how is the role of the endocannabinoid system affected when you take CBD specifically?
Recent studies show that in addition to raising endocannabinoid levels, cannabidiol can protect DNA from oxidative damage and reduce cell multiplication. Rather than adding to the number of cannabinoids in the body, CBD is thought to stimulate the body’s endocannabinoid response.
For those who would like to further boost to their CB receptor function, studies show that extra virgin olive oil and nutmeg may also play a role in boosting the endocannabinoid system. One study showed that administering extra virgin olive oil in human colon cancer cells and rats increased CB1 activity and reduced the pathogenesis of the cancerous activity in the colon cell cultures. Another study indicated that nutmeg may interact with the endocannabinoid system by inhibiting the catabolic enzymes FAAH and MAGL, which are typically associated with breaking down endocannabinoid system and CBD molecules.
Do Animals Have an Endocannabinoid System?
This amazing system is not only present in humans but is shared by vertebrate animals, too—including all mammals, birds, reptiles, and fish. Which means the endocannabinoid system and CBD work together for them, too! As the largest and most prolific system of neurotransmitters in existence, the eCB system is even thought to have developed between 500 and 600 million years ago.
Although we share the eCB system with the animal kingdom, it’s important to be aware that the role of the endocannabinoid system in animals is different. Dogs and cats, for example, have a greater number of endocannabinoid receptors than humans—making them especially sensitive to the effects of cannabis-based products and human CBD oil.
The pet CBD oil that we sell at Kratora is formulated to meet the specific needs of cats and dogs. Pet-safe CBD can be especially beneficial for pets that suffer from pain, anxiety, irritability, and digestive problems.
Source Pure, Premium CBD Oil at Kratora
If you are thinking of purchasing CBD oil for yourself or your pets, we recommend choosing a high-quality product from a trustworthy source like Kratora for the best results with your endocannabinoid system and CBD goals. Our premium CBD oil is pure, 100% THC-free, and comes in eight delicious flavors including Paradise Punch, Pleasant Peppermint, and Chocolate Sundae—making it easier and more enjoyable than ever to enjoy this health-boosting supplement.
Please note that none of the products sold on our website are intended to diagnose, treat, cure, or prevent any disease or medical condition.